Editorial: Innovative strategies in overcoming glioblastoma: advancements in treatment and research - Takeaways - MDSpire

Editorial: Innovative strategies in overcoming glioblastoma: advancements in treatment and research

  • By

  • Raphael Bertani

  • Fabio Torregrossa

  • Felipe Salvagni

  • June 17, 2026

  • 0 min

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  • 1

    Glioblastoma (GBM) remains the most lethal primary brain tumor, with a median survival of approximately 15 months.

  • 2

    Tumor-treating fields are the only treatment addition showing survival benefits in GBM, while other candidates have largely failed.

  • 3

    GBM resistance arises from a network of pathways in an immunosuppressive microenvironment, necessitating combination therapies.

  • 4

    Non-invasive monitoring of GBM through plasma cfDNA is limited by low concentrations, while CSF detection shows higher accuracy.

  • 5

    The Research Topic includes diverse contributions aimed at identifying molecular targets and improving therapeutic strategies for GBM.

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