The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research

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Septic shock has a high mortality rate of 35-40% and is associated with a significant risk of acute kidney injury (AKI).
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Vasopressors are essential for managing septic shock, with norepinephrine recommended as the first-line agent by the Surviving Sepsis Campaign.
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Current evidence on the impact of different vasopressors on renal outcomes in septic shock is limited and often of low quality.
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This systematic review aims to clarify the relationship between vasopressor selection and renal outcomes in adult septic shock patients.
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Improved understanding of vasopressor effects on renal injury is crucial for tailoring therapy and enhancing patient outcomes in septic shock.

Critical Care (Springer)

by Rory McDonald, Michael Burns, Adrian Wong, Carolyn Smith, Marlies Ostermann, Sam Hutchings
October 2, 2025

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