Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis - Takeaways - MDSpire

Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis

  • By

  • Mengwan Hu

  • Lei You

  • Xuezhuo Zhang

  • Zhibo Xuan

  • Sijia Ma

  • Xian Wu

  • July 1, 2026

  • 0 min

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  • 1

    The study systematically evaluated electroacupuncture's therapeutic efficacy in amyotrophic lateral sclerosis using preclinical mouse models.

  • 2

    Seventeen studies involving 372 animals were included, with an average methodological quality score of 7.

  • 3

    Meta-analysis showed significant improvement in motor function in ALS mice receiving electroacupuncture compared to controls.

  • 4

    Electroacupuncture alleviated neuroinflammation, promoted neuronal survival, and improved axonal regeneration in ALS models.

  • 5

    The findings suggest electroacupuncture may serve as a promising multimodal therapeutic strategy for ALS, warranting further clinical investigation.

Original Source(s)

Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis

  • by Mengwan Hu, Lei You, Xuezhuo Zhang, Zhibo Xuan, Sijia Ma, Xian Wu

  • July 1, 2026

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