Shaping the Skeleton: Impact of GnRH Analogue and Sex Hormone Therapy on Skeletal Dimensions in Transgender Individuals

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The study investigates the impact of puberty suppression and gender-affirming hormone therapy on skeletal dimensions in transgender individuals.
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Transgender individuals assigned male at birth who underwent early puberty suppression had smaller shoulder dimensions compared to untreated individuals.
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Pelvic dimensions in transgender individuals assigned male at birth were greater with early and late puberty suppression compared to untreated individuals.
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Only early puberty suppression in transgender individuals assigned female at birth resulted in smaller pelvic inlet width compared to untreated individuals.
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The findings suggest that skeletal dimensions are altered by hormone therapy primarily if puberty suppression occurs before endogenous puberty completion.

The Journal Of Clinical Endocrinology & Metabolism

by Lidewij Sophia Boogers, Boukje Teatske Sikma, Mark-Bram Bouman, Adrianus Sarinus Paulus van Trotsenburg, Martin den Heijer, Chantal Maria Wiepjes, Sabine Elisabeth Hannema
August 16, 2024

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