Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes

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Soraphen A (SorA) inhibits Th17 polarization while preserving regulatory T cells, improving post-stroke outcomes.
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LPS worsens functional outcomes and increases peripheral T cell activation after stroke.
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SorA enhances antigen-specific T cell activation and increases regulatory T cells in LPS-treated mice.
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The Th17/Treg balance is crucial for post-stroke inflammation and recovery, influencing tissue damage.
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Targeting T cell metabolism with SorA presents a promising immunomodulatory strategy for post-stroke recovery.

Frontiers In Immunology

by Juliane Gellrich, Nora Bödecker, Imke Reich, Johanna Ruhnau, Stefan Groß, Susanne H. Kirsch, Rolf Müller, Juliane Schulze, Antje Vogelgesang
May 8, 2026

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