Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa - Takeaways - MDSpire

Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa

  • By

  • Shuai Tang

  • Lei Wang

  • Chong-xi Fan

  • Zhe-yi Han

  • Lei Zhang

  • Bai-rong Li

  • Shou-Bin Ning

  • June 22, 2026

  • 0 min

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  • 1

    Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder linked to STK11/LKB1 mutations, characterized by gastrointestinal hamartomatous polyps.

  • 2

    A study involving 44 PJS patients analyzed mucosa-associated microbiota using 5R 16S rRNA gene sequencing to compare polyps and normal mucosa.

  • 3

    Results showed reduced alpha diversity and increased Simpson index in PJS polyps, indicating significant microbial dysbiosis compared to normal mucosa.

  • 4

    PJS polyps were enriched in Pseudomonadota and depleted in Bacillota and Bacteroidota, with a higher microbial dysbiosis index observed.

  • 5

    A random forest model identified nine genera with potential as biomarkers, correlating specific microbes with polyp number and CA72-4 levels.

Original Source(s)

Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa

  • by Shuai Tang, Lei Wang, Chong-xi Fan, Zhe-yi Han, Lei Zhang, Bai-rong Li, Shou-Bin Ning

  • June 22, 2026

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