Evaluating Blood Culture Parameters to Identify Patients at Low Risk of Infective Endocarditis Among Those With Bacteremia by Gram-positive Cocci - Takeaways - MDSpire

Evaluating Blood Culture Parameters to Identify Patients at Low Risk of Infective Endocarditis Among Those With Bacteremia by Gram-positive Cocci

  • By

  • Nicolas Fourré

  • Virgile Zimmermann

  • Nicoleta Ianculescu

  • Thomas Brahier

  • Zélie Dennebouy

  • André Teixeira-Antunes

  • Pierre Monney

  • Georgios Tzimas

  • Laurence Senn

  • Lars Niclauss

  • Matthias Kirsch

  • Benoit Guery

  • Matthaios Papadimitriou-Olivgeris

  • August 22, 2025

  • 0 min

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  • 1

    The study aimed to assess blood culture parameters for identifying low-risk patients for infective endocarditis (IE) among those with bacteremia.

  • 2

    Low-risk criteria included having only one positive blood culture out of four and bacteremia clearance within 48 hours.

  • 3

    Among 2165 bacteremia episodes, 561 (26%) were diagnosed with IE, with 82% showing more than one positive culture.

  • 4

    A negative likelihood ratio (NLR) of 0.08 was found when combining low-risk criteria, indicating a potential for identifying low-risk patients.

  • 5

    Despite identifying low-risk patients, the approach may classify most as high-risk, limiting its impact on reducing echocardiography use.

Original Source(s)

Evaluating Blood Culture Parameters to Identify Patients at Low Risk of Infective Endocarditis Among Those With Bacteremia by Gram-positive Cocci

  • by Nicolas Fourré, Virgile Zimmermann, Nicoleta Ianculescu, Thomas Brahier, Zélie Dennebouy, André Teixeira-Antunes, Pierre Monney, Georgios Tzimas, Laurence Senn, Lars Niclauss, Matthias Kirsch, Benoit Guery, Matthaios Papadimitriou-Olivgeris

  • August 22, 2025

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