Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis - Takeaways - MDSpire

Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis

  • By

  • Jiafang Fu

  • Jingli Shan

  • Hua Xu

  • Zhiwei Zhu

  • Pengshuo Yang

  • Qinzhou Wang

  • Jinxiang Han

  • Guangxiang Cao

  • June 10, 2026

  • 0 min

Share

  • 1

    Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory disease often triggered by infections, affecting the peripheral nervous system.

  • 2

    This study found significant alterations in GABA and secondary bile acid metabolism in GBS patients, indicating potential metabolic disturbances.

  • 3

    Increased levels of GABA and decreased levels of several secondary cholic acids were observed in GBS subjects compared to healthy controls.

  • 4

    Metagenomic analysis revealed specific gut microbiota changes in GBS, with increased pathogenic bacteria like Klebsiella pneumoniae.

  • 5

    The findings suggest that GABA may serve as a biomarker for GBS and that gut microbiota modulation could influence disease progression.

Original Source(s)

Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis

  • by Jiafang Fu, Jingli Shan, Hua Xu, Zhiwei Zhu, Pengshuo Yang, Qinzhou Wang, Jinxiang Han, Guangxiang Cao

  • June 10, 2026

Related Content

An interpretable TimeMIL framework for fNIRS: differential diagnosis between schizophrenia and bipolar disorder

Investigation of bioimpedance as a method for wearable noninvasive bladder volume measurements in individuals with spinal cord injury or disease: protocol of a feasibility study

Resting-state functional connectivity and local activity differences across bothersome and non-bothersome tinnitus phenotypes