Case Report: A case of incidentally discovered isolated gastric plasmacytoma

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Extramedullary plasmacytoma (EMP) constitutes about 3% of plasma cell neoplasms, with gastric plasmacytoma being a rare subtype at roughly 2% of EMP cases.
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A 53-year-old male presented with persistent acid reflux and heartburn, leading to the discovery of a gastric lesion via gastroscopy.
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Endoscopic mucosal resection confirmed the diagnosis of primary solitary gastric plasmacytoma through histopathology and immunohistochemistry.
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The patient underwent multiple diagnostic tests, including PET-CT and bone marrow aspiration, to exclude multiple myeloma and other conditions.
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Surgical or endoscopic resection is the first-line therapy for early localized gastric plasmacytoma, with no established uniform treatment guidelines.

Frontiers In Oncology

by Ya-nan Zhang, Qing-xin Li, Lin-chong Ma, Yong-tai Jin, Wen-qi Li, Jin-chen Du
July 7, 2026

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