CCDC88C::PDGFRB-Rearranged Myeloid Neoplasm with Predominant Neutrophilia and Rapid Response to Imatinib: A Molecularly Defined Case Report - Takeaways - MDSpire

CCDC88C::PDGFRB-Rearranged Myeloid Neoplasm with Predominant Neutrophilia and Rapid Response to Imatinib: A Molecularly Defined Case Report

  • By

  • Guo, Yafei

  • Wu, Huiqiang

  • Cai, Zhiyin

  • Chen, Genwang

  • Meiling, Li

  • Guo, Xizhe

  • June 22, 2026

  • 0 min

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  • 1

    A 60-year-old male presented with leukocytosis and thrombocytopenia during a routine health assessment.

  • 2

    Bone marrow examination showed significant granulocytic proliferation without increased blasts.

  • 3

    Cytogenetic evaluation identified a t(5;14) translocation, and RNA sequencing revealed a CCDC88C::PDGFRB fusion.

  • 4

    Targeted sequencing also detected an ATM frameshift mutation in the patient.

  • 5

    Treatment with low-dose imatinib led to rapid normalization of leukocyte levels and sustained hematologic remission.

Original Source(s)

CCDC88C::PDGFRB-Rearranged Myeloid Neoplasm with Predominant Neutrophilia and Rapid Response to Imatinib: A Molecularly Defined Case Report

  • by Guo, Yafei , Wu, Huiqiang , Cai, Zhiyin , Chen, Genwang , Meiling, Li , Guo, Xizhe

  • June 22, 2026

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