Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction - Takeaways - MDSpire

Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction

  • By

  • Xin Liu

  • Yuanyuan Ma

  • Hong Cui

  • Qi Feng

  • June 4, 2026

  • 0 min

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  • 1

    Maternal dietary restriction during lactation leads to extrauterine growth restriction (EUGR) in rat offspring, characterized by growth impairment and dyslipidemia.

  • 2

    EUGR pups exhibited significantly lower body weight and length, with altered serum lipid profiles, including reduced triglycerides and elevated HDL-C.

  • 3

    Recombinant human IGF-1 treatment did not improve growth in EUGR pups but significantly reduced HDL-C levels compared to the control group.

  • 4

    Liver transcriptomic analysis revealed increased expression of lipoprotein lipase (LPL) in EUGR rats, indicating altered lipid metabolism.

  • 5

    In vitro studies showed that LPL overexpression downregulated lipogenic genes ACACA and SCD, suggesting a pathway for triglyceride alterations in EUGR.

Original Source(s)

Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction

  • by Xin Liu, Yuanyuan Ma, Hong Cui, Qi Feng

  • June 4, 2026

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