Interleukin-40 as a biomarker of mortality risk in patients with severe pneumonia - Takeaways - MDSpire

Interleukin-40 as a biomarker of mortality risk in patients with severe pneumonia

  • By

  • Hong Tan

  • Hanyi Wang

  • Xuanyi Zhou

  • Jun Duan

  • Xiaoliang Yang

  • May 28, 2026

  • 0 min

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  • 1

    Interleukin-40 (IL-40) levels at ICU admission are significantly higher in severe pneumonia patients compared to non-severe pneumonia patients and healthy controls.

  • 2

    Non-survivors of severe pneumonia exhibit significantly elevated IL-40 levels compared to survivors, indicating its potential as a mortality predictor.

  • 3

    The area under the receiver operating characteristic curve (AUC) for IL-40 in predicting 28-day mortality in severe pneumonia is the highest among evaluated indicators.

  • 4

    IL-40 combined with Sequential Organ Failure Assessment (SOFA) scores improves the AUC for estimating mortality risk from 0.7626 to 0.7980.

  • 5

    Patients with severe pneumonia showing IL-40 levels ≥1.244 ng/mL have poorer survival outcomes than those with lower levels, highlighting its prognostic value.

Original Source(s)

Interleukin-40 as a biomarker of mortality risk in patients with severe pneumonia

  • by Hong Tan, Hanyi Wang, Xuanyi Zhou, Jun Duan, Xiaoliang Yang

  • May 28, 2026

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