Comparative efficacy and cognitive safety of bifrontal versus bitemporal electroconvulsive therapy in adolescents with major depressive disorder: a retrospective cohort study - Takeaways - MDSpire
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Efficacy and Cognitive Safety Comparison of Bifrontal and Bitemporal Electroconvulsive Therapy in Adolescents with Major Depressive Disorder: A Retrospective Cohort Analysis

  • By

  • Xiaolu Chen

  • Ke Liu

  • Xiaoshan Shen

  • Yifan Yang

  • Hao Yu

  • Qibing Chen

  • Xiaoli Wang

  • Xiao Li

  • August 26, 2026

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  • 1

    A retrospective cohort study analyzed 217 adolescents with major depressive disorder receiving ECT from January 2018 to June 2024.

  • 2

    Bifrontal ECT showed a numerically higher response rate (85.6%) compared to bitemporal ECT (82.1%), but the difference was not statistically significant.

  • 3

    Subjective memory complaints were significantly lower in the bifrontal group (28.8%) compared to the bitemporal group (67.9%), indicating better cognitive safety.

  • 4

    Post-ictal recovery time was shorter for bifrontal ECT at 23.7 minutes, compared to 33.4 minutes for bitemporal ECT, suggesting quicker recovery.

  • 5

    The study highlights the need for further prospective controlled studies to confirm findings due to its retrospective nature and non-random treatment allocation.

Original Source(s)

Comparative efficacy and cognitive safety of bifrontal versus bitemporal electroconvulsive therapy in adolescents with major depressive disorder: a retrospective cohort study

  • by Xiaolu Chen, Ke Liu, Xiaoshan Shen, Yifan Yang, Hao Yu, Qibing Chen, Xiaoli Wang, Xiao Li

  • August 26, 2026

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