The negative prognostic effect of diminished chemotherapy dose intensity is less pronounced in early breast cancer patients experiencing treatment-related neutropenia: findings from a retrospective cohort analysis - Takeaways - MDSpire

The negative prognostic effect of diminished chemotherapy dose intensity is less pronounced in early breast cancer patients experiencing treatment-related neutropenia: findings from a retrospective cohort analysis

  • By

  • K. Eissler

  • T. Engler

  • D. Dannehl

  • B. Schönfisch

  • J. Englisch

  • A. D. Hartkopf

  • S. Y. Brucker

  • E. M. Grischke

  • L. L. Volmer

  • Alexander Englisch

  • April 21, 2026

  • 0 min

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  • 1

    Reduced relative dose intensity (RDI) < 85% was linked to worse survival mainly in patients without treatment-related neutropenia (rCIN).

  • 2

    Patients with rCIN did not show significant survival differences despite lower chemotherapy intensity compared to those without rCIN.

  • 3

    Chemotherapy-induced neutropenia (CIN) may indicate increased chemosensitivity, potentially mitigating the negative effects of reduced RDI.

  • 4

    The study analyzed early breast cancer patients receiving neoadjuvant or adjuvant chemotherapy at a single center from 2014 to 2021.

  • 5

    Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier estimates and Cox proportional hazards models.

Original Source(s)

The negative prognostic effect of diminished chemotherapy dose intensity is less pronounced in early breast cancer patients experiencing treatment-related neutropenia: findings from a retrospective cohort analysis

  • by K. Eissler, T. Engler, D. Dannehl, B. Schönfisch, J. Englisch, A. D. Hartkopf, S. Y. Brucker, E. M. Grischke, L. L. Volmer, Alexander Englisch

  • April 21, 2026

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