Effect of preoperative anemia on surgical outcomes in endonasal transsphenoidal surgery for pituitary adenoma: a matched-cohort study - Takeaways - MDSpire

Effect of preoperative anemia on surgical outcomes in endonasal transsphenoidal surgery for pituitary adenoma: a matched-cohort study

  • By

  • Khor, Wei-Thing

  • Wong, Chia-En

  • Chang, Yu

  • Perng, Pang-Shuo

  • Lee, Po-Hsuan

  • Huang, Chi-Chen

  • Tien, Chih-Hao

  • Huang, Kuo-Chang

  • Lee, Jung-Shun

  • February 27, 2026

  • 0 min

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  • 1

    Preoperative anemia is associated with increased morbidity and mortality in various surgical procedures, including endonasal transsphenoidal surgery for pituitary adenomas.

  • 2

    Patients with preoperative anemia experienced higher rates of postoperative meningitis, lumbar drain placement, and early reoperation compared to non-anemic patients.

  • 3

    The incidence of postoperative diabetes insipidus was significantly higher in the anemic group, indicating a link between anemia and neuroendocrine dysfunction.

  • 4

    Statistical analyses showed that preoperative anemia correlated with worse perioperative and neuroendocrine functional outcomes after surgery for pituitary adenomas.

  • 5

    The study highlights the importance of optimizing hemoglobin and hematocrit levels preoperatively to improve surgical outcomes in patients with pituitary adenomas.

Original Source(s)

Effect of preoperative anemia on surgical outcomes in endonasal transsphenoidal surgery for pituitary adenoma: a matched-cohort study

  • by Khor, Wei-Thing, Wong, Chia-En, Chang, Yu, Perng, Pang-Shuo, Lee, Po-Hsuan, Huang, Chi-Chen, Tien, Chih-Hao, Huang, Kuo-Chang, Lee, Jung-Shun

  • February 27, 2026

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