Utility of miRNA biomarkers in patients with acute myocardial infarction (UNIAMI)—results from a prospective pilot study - Takeaways - MDSpire

Utility of miRNA biomarkers in patients with acute myocardial infarction (UNIAMI)—results from a prospective pilot study

  • By

  • Chakradhara Rao S. Uppugunduri

  • Koustav Sarkar

  • Oishi Mukherjee

  • Kaviya Manoharan

  • Iyshwarya B. K

  • Melvin George

  • June 11, 2026

  • 0 min

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  • 1

    The study enrolled 216 participants, including 45 AMI patients, 71 stable CAD patients, and 100 healthy controls, to investigate miRNA biomarkers.

  • 2

    Significant upregulation of specific miRNAs was observed in AMI patients, indicating their potential as biomarkers for diagnosis and prognosis.

  • 3

    Pathway enrichment analysis implicated key molecular processes such as ECM-receptor interaction and PI3K/AKT signaling in AMI.

  • 4

    ROC analysis showed excellent discriminatory performance of miR-4485-3p with an AUC of 1.000, highlighting its diagnostic potential.

  • 5

    The findings emphasize the need for population-specific data on circulating miRNAs to enhance understanding of AMI in South Indian individuals.

Original Source(s)

Utility of miRNA biomarkers in patients with acute myocardial infarction (UNIAMI)—results from a prospective pilot study

  • by Chakradhara Rao S. Uppugunduri, Koustav Sarkar, Oishi Mukherjee, Kaviya Manoharan, Iyshwarya B. K, Melvin George

  • June 11, 2026

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