Efficacy and safety of quadruple therapy versus triple therapy in patients with heart failure with preserved ejection fraction: a propensity score-matched real-world study - Takeaways - MDSpire

Comparative Analysis of Quadruple Therapy Versus Triple Therapy in Patients with Heart Failure and Preserved Ejection Fraction: A Real-World Study Utilizing Propensity Score Matching

  • By

  • Jian Shi

  • Linglin Fang

  • Xiaoyue Cai

  • Hao Wu

  • Xiaoyu Yang

  • Liping Wei

  • July 20, 2026

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  • 1

    This study analyzed 600 patients with heart failure and preserved ejection fraction (HFpEF) receiving triple therapy at a single center.

  • 2

    Quadruple therapy significantly reduced the incidence of heart failure hospitalization or cardiovascular death compared to triple therapy.

  • 3

    The quadruple therapy group had lower rates of first and recurrent heart failure hospitalization during a median follow-up of 37.8 months.

  • 4

    Subgroup analyses indicated greater benefits of quadruple therapy in patients with coronary artery disease and higher baseline heart rates.

  • 5

    No significant differences in cardiovascular or all-cause mortality were observed between the quadruple and triple therapy groups.

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