Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson’s and dementia with Lewy bodies - Takeaways - MDSpire

Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson’s and dementia with Lewy bodies

  • By

  • Notash Shafiei

  • Daria Proniakova

  • Marija Simjanoska

  • Anniken Mathea Rafnum Sjødal

  • Daniel Stähli

  • Lukas van den Heuvel

  • Marta Di Fabrizio

  • Eve Aaron

  • Sandor Kasas

  • Mathis Solal Krause

  • Mallory Wittwer

  • Julika Radecke

  • Henning Stahlberg

  • Wilma D. J. van de Berg

  • Amanda J. Lewis

  • July 8, 2026

  • 0 min

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  • 1

    Parkinson's disease and dementia with Lewy bodies are characterized by abnormal accumulation of alpha-synuclein forming Lewy bodies and Lewy neurites.

  • 2

    The study utilized correlative light and electron microscopy to investigate regional diversity of alpha-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.

  • 3

    Findings revealed that Lewy body ultrastructure varies by brain region, with distinct fibrillar densities observed in the entorhinal cortex and anterior cingulate cortex.

  • 4

    The research also uncovered regional and disease-specific differences in mitochondrial morphology associated with alpha-synuclein inclusions.

  • 5

    This study extends previous descriptions of cortical Lewy pathology, highlighting its regional heterogeneity and molecular complexity in Parkinson's disease and dementia with Lewy bodies.

Original Source(s)

Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson’s and dementia with Lewy bodies

  • by Notash Shafiei, Daria Proniakova, Marija Simjanoska, Anniken Mathea Rafnum Sjødal, Daniel Stähli, Lukas van den Heuvel, Marta Di Fabrizio, Eve Aaron, Sandor Kasas, Mathis Solal Krause, Mallory Wittwer, Julika Radecke, Henning Stahlberg, Wilma D. J. van de Berg, Amanda J. Lewis

  • July 8, 2026

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