A Comparative Analysis of Eradication Success, Side Effects, and Adherence in Pediatric Patients Treated with Triple Therapy Versus Bismuth-Containing Quadruple Therapy for Helicobacter pylori Infection - Takeaways - MDSpire

A Comparative Analysis of Eradication Success, Side Effects, and Adherence in Pediatric Patients Treated with Triple Therapy Versus Bismuth-Containing Quadruple Therapy for Helicobacter pylori Infection

  • By

  • Yonghao Qian

  • Xiaozhen Hua

  • April 22, 2026

  • 0 min

Share

  • 1

    Bismuth-containing quadruple therapy achieved a significantly higher eradication rate of 90.36% compared to 74.36% for triple therapy (P = 0.007).

  • 2

    Post-treatment symptom scores for abdominal pain, bloating, and nausea improved more with bismuth-containing quadruple therapy than with triple therapy (P < 0.05).

  • 3

    In patients with successful eradication, bismuth-containing quadruple therapy resulted in lower abdominal pain scores, indicating its potential independent effect on pain relief (P = 0.002).

  • 4

    The incidence of adverse events and medication compliance rates were similar between the bismuth-containing quadruple therapy and triple therapy groups (P > 0.05).

  • 5

    Bismuth-containing quadruple therapy is a promising alternative to triple therapy for treating H. pylori infection in children, with comparable safety and improved efficacy.

Original Source(s)

Related Content