Mental fatigue and cognitive functioning in patients presenting with non-enhancing gliomas

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Diffuse gliomas are primary brain tumors that worsen over time, with lower-grade gliomas (LGG) classified as grade 2–3 according to WHO 2021.
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Mental fatigue is a significant self-reported symptom in LGG patients, impacting cognitive functioning and health-related quality of life.
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The study aimed to analyze the association between mental fatigue and cognitive functioning in LGG patients prior to surgical treatment.
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A total of 101 patients with presumed LGG were included in the study, undergoing clinical examination and neuropsychological testing.
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Neuropsychological tests assessed various cognitive domains, with impairment defined as scores below 35 on standardized t-scores.

Acta Neurochirurgica

by Alice Neimantaite, Tomás Gómez Vecchio, Isabelle Rydén, Dima Harba, Asgeir S. Jakola, Anja Smits
March 8, 2025

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