A Two-Biomarker Signal for Alzheimer’s Disease

Dual plasma biomarkers may improve identification of established Alzheimer’s disease and signal faster decline

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A combination of eMTBR-tau243 and plasma p-tau217 improves identification of established Alzheimer's disease.
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The study involved 572 patients with cognitive symptoms, assessed through clinical evaluation and biomarker testing.
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The two-biomarker approach showed 81% accuracy and 84% positive predictive value for established Alzheimer's disease.
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Higher eMTBR-tau243 levels correlated with greater tau accumulation and faster cognitive decline over time.
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The findings support a two-step testing strategy to differentiate asymptomatic amyloid pathology from significant Alzheimer's disease.

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