Systematic review: The management of unhealed wounds and persistent perineal sinuses following proctectomy in inflammatory bowel disease - Takeaways - MDSpire

Systematic review: The management of unhealed wounds and persistent perineal sinuses following proctectomy in inflammatory bowel disease

  • By

  • T. Pelly

  • E. Anand

  • S. Holubar

  • P. Tozer

  • A. Hart

  • December 8, 2025

  • 0 min

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  • 1

    Unhealed perineal wounds and persistent perineal sinuses are significant complications following proctectomy in inflammatory bowel disease.

  • 2

    Between 25% and 33% of patients with perianal Crohn’s disease experience unhealed wounds after 12 months post-surgery.

  • 3

    Treatment options for unhealed wounds and PPS include advanced medical therapies, surgical interventions, and novel approaches like hyperbaric oxygen therapy.

  • 4

    The systematic review included 25 studies, primarily retrospective, with most demonstrating poor methodological quality.

  • 5

    No current guidelines exist for treating unhealed wounds/PPS, highlighting the need for further research and standardized classification.

Original Source(s)

Systematic review: The management of unhealed wounds and persistent perineal sinuses following proctectomy in inflammatory bowel disease

  • by T. Pelly, E. Anand, S. Holubar, P. Tozer, A. Hart

  • December 8, 2025

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