Case Report: Cardiac metastasis of sarcomatoid urothelial carcinoma - Takeaways - MDSpire

Case Report: Cardiac metastasis of sarcomatoid urothelial carcinoma

  • By

  • Nan Ma

  • Jing Wang

  • Miaomiao Ma

  • Liping Yang

  • May 12, 2026

  • 0 min

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  • 1

    Sarcomatoid urothelial carcinoma (SUC) is a rare and aggressive subtype of urothelial carcinoma, comprising less than 2% of all cases.

  • 2

    A 55-year-old woman with right renal pelvis SUC developed isolated cardiac metastasis, confirmed by echocardiography.

  • 3

    Initial treatment with chemo-immunotherapy was halted due to severe myelosuppression, leading to a switch to tislelizumab monotherapy.

  • 4

    Tislelizumab treatment resulted in significant regression of the right ventricular mass, suggesting potential efficacy in cardiac metastasis.

  • 5

    This case highlights the aggressive nature of SUC and the potential role of immune checkpoint inhibitors for patients intolerant to traditional therapies.

Original Source(s)

Case Report: Cardiac metastasis of sarcomatoid urothelial carcinoma

  • by Nan Ma, Jing Wang, Miaomiao Ma, Liping Yang

  • May 12, 2026

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