GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis - Takeaways - MDSpire

GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis

  • By

  • Silan Shen

  • Kexin Chen

  • Lili Li

  • Mingshan Jiang

  • Yongbin Jia

  • Xiufeng Bai

  • Zhen Zeng

  • Chunxiang Ma

  • Yuan Dang

  • Kehan Hu

  • Yanqiong Chen

  • Wenting Zhang

  • Zhiyong Miao

  • Linlin Chen

  • Hu Zhang

  • June 26, 2026

  • 0 min

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  • 1

    GM-CSF expression is significantly elevated in colon biopsy tissues from ulcerative colitis patients compared to healthy controls.

  • 2

    Administration of GM-CSF neutralizing antibody in DSS-treated mice attenuates gut inflammation and inhibits macrophage infiltration.

  • 3

    GM-CSF induces M1-type polarization of macrophages, enhancing the Th17 response and contributing to intestinal inflammation.

  • 4

    The proinflammatory macrophage phenotype induced by GM-CSF is linked to glycolytic metabolism influenced by the Akt/mTOR pathway.

  • 5

    This study highlights the role of GM-CSF in regulating macrophage function and metabolism in the context of intestinal inflammation.

Original Source(s)

GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis

  • by Silan Shen, Kexin Chen, Lili Li, Mingshan Jiang, Yongbin Jia, Xiufeng Bai, Zhen Zeng, Chunxiang Ma, Yuan Dang, Kehan Hu, Yanqiong Chen, Wenting Zhang, Zhiyong Miao, Linlin Chen, Hu Zhang

  • June 26, 2026

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