Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents - Takeaways - MDSpire

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • By

  • Kostinov, Mikhail

  • Prutskova, Ekaterina

  • Mekhantseva, Irina

  • Cherdantsev, Alexander

  • Solovеva, Irina

  • Polishchuk, Valentina

  • Zhestkov, Alexander

  • Khamidulina, Anna

  • Dementeva, Yuliya

  • Kostinov, Anton

  • Khrapunova, Isabella

  • Loktionova, Marina

  • Tarasova, Alla

  • Kvasova, Maria

  • Poddubikov, Arseniy

  • Pal, Nidhi Harish

  • Kostinova, Aristitsa

  • June 2, 2026

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  • 1

    The study assessed IgG levels before and after booster vaccination for diphtheria, tetanus, and pertussis in 121 adolescents aged 14.

  • 2

    All participants had protective immunity to tetanus, while 1.7% lacked protective levels against diphtheria and 6.9% against pertussis at baseline.

  • 3

    Booster vaccination significantly increased anti-diphtheria IgG levels across all vaccine groups, with no significant differences between formulations.

  • 4

    Tetanus-specific antibody levels were high in all adolescents, with the Td-M group showing the highest titers and strong anamnestic responses.

  • 5

    Pertussis-specific IgG responses were heterogeneous, showing no overall increase post-vaccination, indicating limited booster-induced expansion.

Original Source(s)

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • by Kostinov, Mikhail , Prutskova, Ekaterina , Mekhantseva, Irina , Cherdantsev, Alexander , Solovеva, Irina , Polishchuk, Valentina , Zhestkov, Alexander , Khamidulina, Anna , Dementeva, Yuliya , Kostinov, Anton , Khrapunova, Isabella , Loktionova, Marina , Tarasova, Alla , Kvasova, Maria , Poddubikov, Arseniy , Pal, Nidhi Harish, Kostinova, Aristitsa

  • June 2, 2026

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