CT imaging features of pulmonary SMARCA4-deficient undifferentiated carcinoma: a retrospective case series

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Pulmonary SMARCA4-deficient undifferentiated carcinoma is a rare, aggressive lung cancer with poor prognosis and nonspecific imaging features.
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The study analyzed CT imaging characteristics in 15 patients, revealing tumors typically as solid masses with a median diameter of 3.7 cm.
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Aggressive imaging features included spiculated margins (93.3%), intratumoral necrosis (86.7%), and cavitation (46.7%).
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Invasion of adjacent structures was common, with bronchial involvement in 86.7% and vascular invasion in 80.0% of cases.
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Key imaging features showed good-to-excellent interobserver agreement, aiding in the suspicion of this carcinoma over other malignancies.

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