Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis

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Atherosclerosis is a chronic inflammatory disease driven by lipid metabolic dysregulation and immune cell interactions.
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Key regulatory proteins, including epigenetic modifiers and transcription factors, play critical roles in atherogenesis.
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Histone deacetylases (HDACs) exhibit isoform-specific effects on atherosclerosis, influencing inflammation and vascular remodeling.
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HDAC3 has dual roles, exacerbating inflammation in macrophages while also exhibiting protective signaling in vascular smooth muscle cells.
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The review emphasizes the importance of understanding complex molecular networks for developing precision-targeted therapies for cardiovascular disease.

Frontiers In Immunology

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