Exploring the Neurobiological Markers of Suicidal Behaviors in Pediatric Population: A Narrative Review - Takeaways - MDSpire

Exploring the Neurobiological Markers of Suicidal Behaviors in Pediatric Population: A Narrative Review

  • By

  • Salehi, Mona

  • Saeidi, Mahdieh

  • Amanat, Man

  • Barias, Tala

  • Anyeji, Urenna

  • Alzein, Omar

  • Gunturu, Sasidhar

  • May 13, 2026

  • 0 min

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  • 1

    Suicide is the second leading cause of death among children and adolescents, with rising rates over the past two decades.

  • 2

    Current evidence on neurobiological correlates of suicidal behavior in youth is limited compared to adult studies.

  • 3

    Distinct biological signatures exist for suicidal ideation, attempts, and death by suicide in pediatric populations.

  • 4

    Cortisol regulation and stress-related DNA methylation show differing patterns between pediatric and adult cohorts.

  • 5

    Advancing research requires longitudinal studies that focus on pediatric populations and disaggregate suicidal phenotypes.

Original Source(s)

Exploring the Neurobiological Markers of Suicidal Behaviors in Pediatric Population: A Narrative Review

  • by Salehi, Mona , Saeidi, Mahdieh , Amanat, Man , Barias, Tala , Anyeji, Urenna , Alzein, Omar , Gunturu, Sasidhar

  • May 13, 2026

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