Integrative RNA-seq and iRIP-seq analysis links SNRPA overexpression to transcriptomic and splicing alterations in hepatocellular carcinoma cells - Takeaways - MDSpire

Integrative RNA-seq and iRIP-seq analysis links SNRPA overexpression to transcriptomic and splicing alterations in hepatocellular carcinoma cells

  • By

  • Qingyao Chang

  • Yidi Wang

  • Jun Xu

  • May 1, 2026

  • 0 min

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  • 1

    SNRPA overexpression in HepG2 cells leads to significant transcriptomic changes, including 498 differentially expressed genes and 2316 alternative splicing events.

  • 2

    iRIP-seq identified transcripts associated with SNRPA that exhibited altered expression and splicing, many linked to hepatocellular carcinoma mechanisms.

  • 3

    Twelve RNA-binding proteins involved in HCC were modulated by SNRPA overexpression, affecting alternative splicing, mRNA stability, and translational regulation.

  • 4

    Functional annotation revealed that overlapping genes are enriched in pathways related to RNA processing, transcription, and cell division.

  • 5

    The study suggests SNRPA may play dual roles in RNA binding and splicing modulation, influencing hepatocellular carcinoma progression.

Original Source(s)

Integrative RNA-seq and iRIP-seq analysis links SNRPA overexpression to transcriptomic and splicing alterations in hepatocellular carcinoma cells

  • by Qingyao Chang, Yidi Wang, Jun Xu

  • May 1, 2026

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