Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients - Takeaways - MDSpire
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Staphylococcus aureus Serine Protease-Like Protein B Induces Type 1 and Type 2 Immune Responses in Patients with Atopic Dermatitis

  • By

  • Rebecca Pospich

  • Goran Abdurrahman

  • Tatjana Honstein

  • Maria Nordengrün

  • Stephan Traidl

  • Gabriele Begemann

  • Petra Kienlin

  • Thomas Werfel

  • Barbara M. Bröker

  • Lennart M. Roesner

  • June 4, 2026

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  • 1

    Atopic dermatitis (AD) is characterized by type-2 inflammation and is influenced by Staphylococcus aureus colonization.

  • 2

    Patients with AD exhibit significantly elevated IgE levels against Staphylococcus aureus serine protease-like proteins.

  • 3

    Recombinant SplB can activate T cells and induce cytokine secretion in both AD patients and healthy controls.

  • 4

    Clonal SplB-specific T cells producing IFN-γ and IL-13 were identified in the skin of AD patients.

  • 5

    The study suggests that the adaptive immune response to SplB contributes to inflammation and chronicity in AD.

Original Source(s)

Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients

  • by Rebecca Pospich, Goran Abdurrahman, Tatjana Honstein, Maria Nordengrün, Stephan Traidl, Gabriele Begemann, Petra Kienlin, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner

  • June 4, 2026

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