Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients

1

Atopic dermatitis (AD) is characterized by type-2 inflammation and is influenced by Staphylococcus aureus colonization.
2

Patients with AD exhibit significantly elevated IgE levels against Staphylococcus aureus serine protease-like proteins.
3

Recombinant SplB can activate T cells and induce cytokine secretion in both AD patients and healthy controls.
4

Clonal SplB-specific T cells producing IFN-γ and IL-13 were identified in the skin of AD patients.
5

The study suggests that the adaptive immune response to SplB contributes to inflammation and chronicity in AD.

Frontiers In Immunology

by Rebecca Pospich, Goran Abdurrahman, Tatjana Honstein, Maria Nordengrün, Stephan Traidl, Gabriele Begemann, Petra Kienlin, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner
June 4, 2026

1