Case Report Shows Carbimazole's ‘Triple-Hit’ - Takeaways - MDSpire

Case Report Shows Carbimazole's ‘Triple-Hit’

Diffuse alveolar hemorrhage with coexistent antiphospholipid syndrome complicated anticoagulation therapy and created competing bleeding and thrombosis risks.

  • By

  • Andrea Surnit

  • April 1, 2026

  • 3 min

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  • 1

    A 29-year-old female with hyperthyroidism developed microscopic polyangiitis and antiphospholipid syndrome after long-term carbimazole use.

  • 2

    The patient presented with hemoptysis and respiratory failure, with imaging revealing diffuse alveolar hemorrhage.

  • 3

    Treatment included pulse methylprednisolone, intravenous cyclophosphamide, and plasmapheresis, leading to stabilization.

  • 4

    The case exemplified a 'triple-hit' scenario involving vasculitis, thrombosis, and immune-complex deposition.

  • 5

    After treatment, the patient achieved remission and successfully reintroduced carbimazole without recurrence of vasculitis.

Original Source(s)

Case Report Shows Carbimazole's ‘Triple-Hit’

  • by Andrea Surnit

  • April 1, 2026

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