Neuropsychiatric symptom profile in neurocognitive disorders and their relationship with functional decline - Takeaways - MDSpire

Neuropsychiatric symptom profile in neurocognitive disorders and their relationship with functional decline

  • By

  • Carolyn W. Zhu

  • Lon S. Schneider

  • Gregory A. Elder

  • Laili Soleimani

  • Judith Neugroschl

  • Corbett Schimming

  • Mary Sano

  • July 6, 2026

  • 0 min

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  • 1

    Neuropsychiatric symptoms (NPS) are prevalent in neurocognitive disorders (NCD) and negatively affect functional abilities.

  • 2

    Apathy was the most common and persistent NPS across dementia types, linked to rapid functional decline in Alzheimer's disease and bvFTD.

  • 3

    Depression was prevalent in over 40% of participants but did not correlate with worsening functional impairment in any dementia group.

  • 4

    Disinhibition was more frequent in bvFTD compared to Alzheimer's disease and Lewy Body Disease, indicating distinct symptom patterns.

  • 5

    Psychosis and agitation uniquely impacted functional decline in Alzheimer's disease and Lewy Body Disease, respectively.

Original Source(s)

Neuropsychiatric symptom profile in neurocognitive disorders and their relationship with functional decline

  • by Carolyn W. Zhu, Lon S. Schneider, Gregory A. Elder, Laili Soleimani, Judith Neugroschl, Corbett Schimming, Mary Sano

  • July 6, 2026

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