Sex-specific Association of Chronic Proton Pump Inhibitor Use With Reduced Bone Density and Quality - Takeaways - MDSpire

Sex-specific Association of Chronic Proton Pump Inhibitor Use With Reduced Bone Density and Quality

  • By

  • Fabio Bioletto

  • Alessia Pusterla

  • Federica Fraire

  • Lorenzo Sauro

  • Michela Presti

  • Emanuela Arvat

  • Ezio Ghigo

  • Massimo Procopio

  • Marco Barale

  • August 28, 2024

  • 0 min

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  • 1

    Chronic proton pump inhibitor (PPI) use is linked to worse bone health in men, evidenced by lower trabecular bone score (TBS) and lumbar spine T-scores.

  • 2

    No significant association was found between chronic PPI use and bone density or TBS in women, indicating a gender-differentiated impact.

  • 3

    The study utilized data from the National Health and Nutrition Examination Survey (NHANES) to analyze the effects of chronic PPI use on bone density.

  • 4

    Trabecular bone score (TBS) serves as a valuable metric for assessing bone microarchitectural integrity, beyond traditional bone density measurements.

  • 5

    Findings suggest that chronic PPI use may contribute to increased bone fragility, particularly in men, highlighting the need for gender-specific assessments.

Original Source(s)

Sex-specific Association of Chronic Proton Pump Inhibitor Use With Reduced Bone Density and Quality

  • by Fabio Bioletto, Alessia Pusterla, Federica Fraire, Lorenzo Sauro, Michela Presti, Emanuela Arvat, Ezio Ghigo, Massimo Procopio, Marco Barale

  • August 28, 2024

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