Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer’s disease - Takeaways - MDSpire

Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer’s disease

  • By

  • Sergio F Sharif

  • Dylan X Guan

  • Tamara S Bodnar

  • Jeffery T Joseph

  • Henrik Zetterberg

  • Eric E Smith

  • Zahinoor Ismail

  • April 25, 2025

  • 0 min

Share

  • 1

    Neuropsychiatric symptoms (NPS) are linked to a higher risk of progression to Alzheimer's disease (AD) in older adults without dementia.

  • 2

    The mild behavioural impairment (MBI) construct identifies individuals with persistent NPS as high-risk for cognitive decline and incident dementia.

  • 3

    Individuals with AD pathology were 88.4% more likely to exhibit MBI compared to those without AD pathology, indicating a strong association.

  • 4

    MBI+ individuals had a 2.03-fold greater progression rate to AD dementia than those without NPS, highlighting the prognostic value of MBI.

  • 5

    The study suggests incorporating MBI into clinical frameworks may improve early identification of neurodegenerative diseases for treatment selection.

Original Source(s)

Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer’s disease

  • by Sergio F Sharif, Dylan X Guan, Tamara S Bodnar, Jeffery T Joseph, Henrik Zetterberg, Eric E Smith, Zahinoor Ismail

  • April 25, 2025

Related Content

Home Health Value-Based Purchasing and Postacute Home Health Visits Among Older Adults With Dementia

The inhibition of the Aβ-ASC interaction site suppresses β-amyloid aggregation and cytotoxicity

AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases