A Systematic Review of Electrochemotherapy Applications in Pediatric Patients

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Electrochemotherapy (ECT) enhances drug delivery by combining chemotherapeutic agents with electroporation, increasing cell membrane permeability.
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Bleomycin is the most commonly used drug in ECT, significantly increasing its cytotoxicity, while cisplatin is used in specific cases.
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ECT has shown high response rates in adult oncology, with studies indicating its feasibility and safety for treating various tumors.
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Despite its potential, ECT is underutilized in pediatrics due to limited data and concerns about long-term effects.
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This systematic review aims to summarize ECT applications, treatment approaches, and outcomes specifically for pediatric patients.

European Radiology (Springer)

by M. A. Formstone, J. J. Neville, A. N. Smith, A. C. Sedgwick, I. Diez-Perez, P. A. Patel, J. Anderson, S. Giuliani
April 22, 2026

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