Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer - Takeaways - MDSpire

Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer

  • By

  • Shanshan Wang

  • Zhengguang Guo

  • Boyu Sun

  • Kai Liu

  • Jiashuo Chao

  • Ziyu Xun

  • Yunchao Wang

  • Zibo Xu

  • Ziyue Huang

  • Hao Wang

  • Yang Tan

  • Nan Zhang

  • Mingjian Piao

  • Longhao Zhang

  • Chengjie Li

  • Shuofeng Li

  • Jiongyuan Li

  • Haidan Sun

  • Feng Qi

  • Aiwei Wang

  • XiaoBo Yang

  • Chengpei Zhu

  • Hanping Wang

  • Wei Sun

  • Haitao Zhao

  • July 1, 2026

  • 0 min

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  • 1

    Urinary proteomics provides a non-invasive method to predict immune checkpoint inhibitor responsiveness in biliary tract cancer.

  • 2

    Protein tyrosine phosphatase non-receptor 13 is identified as a potential biomarker and therapeutic target for improving immunotherapy outcomes.

  • 3

    The study integrates urinary proteomics with single-cell and spatial transcriptomics to reveal insights into the tumor microenvironment.

  • 4

    Urinary proteomic profiling may enable timely therapeutic adjustments and enhance the application of liquid biopsies in immuno-oncology.

  • 5

    This research highlights the need for dynamic biomarkers to monitor immune-tumor interactions and predict responses to immunotherapy.

Original Source(s)

Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer

  • by Shanshan Wang, Zhengguang Guo, Boyu Sun, Kai Liu, Jiashuo Chao, Ziyu Xun, Yunchao Wang, Zibo Xu, Ziyue Huang, Hao Wang, Yang Tan, Nan Zhang, Mingjian Piao, Longhao Zhang, Chengjie Li, Shuofeng Li, Jiongyuan Li, Haidan Sun, Feng Qi, Aiwei Wang, XiaoBo Yang, Chengpei Zhu, Hanping Wang, Wei Sun, Haitao Zhao

  • July 1, 2026

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