Repeat Influenza Vaccination Effects in 2021/22 and 2022/23 in a Community-Based Cohort in Hong Kong - Takeaways - MDSpire

Repeat Influenza Vaccination Effects in 2021/22 and 2022/23 in a Community-Based Cohort in Hong Kong

  • By

  • Jennifer C Zhong

  • Shuyi Zhong

  • Lisa Touyon

  • Faith Ho

  • Niki Y M Au

  • Samuel M S Cheng

  • Dennis K M Ip

  • Malik Peiris

  • Emily T Martin

  • Sarah Cobey

  • Sook-San Wong

  • Nancy H L Leung

  • Benjamin J Cowling

  • January 28, 2026

  • 0 min

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  • 1

    Repeated influenza vaccination may lead to attenuated immune responses and reduced clinical effectiveness compared to first-time vaccinees.

  • 2

    The study analyzed antibody responses in a Hong Kong cohort during the 2021/22 and 2022/23 influenza seasons, focusing on titer boosting and waning rates.

  • 3

    Participants with higher vaccination uptake showed slower antibody waning against specific strains but reached similar titers at 6 months post-vaccination.

  • 4

    The findings indicate that repeated vaccination is associated with reduced titer increase at 14 days post-vaccination.

  • 5

    The study highlights the need for further understanding of how repeated influenza vaccination affects long-term antibody responses.

Original Source(s)

Repeat Influenza Vaccination Effects in 2021/22 and 2022/23 in a Community-Based Cohort in Hong Kong

  • by Jennifer C Zhong, Shuyi Zhong, Lisa Touyon, Faith Ho, Niki Y M Au, Samuel M S Cheng, Dennis K M Ip, Malik Peiris, Emily T Martin, Sarah Cobey, Sook-San Wong, Nancy H L Leung, Benjamin J Cowling

  • January 28, 2026

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