Associations between CT characteristics of lung cancer lesions and histologic subtypes in lung cancer screening - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

CT Features of Lung Cancer Lesions and Their Associations With Histologic Subtypes in Screening Programs

  • By

  • Erick Suazo-Zepeda

  • Geertruida H. de Bock

  • Noa Antonissen

  • Colin Jacobs

  • Firdaus A. A. Mohamed Hoesein

  • Hester A. Gietema

  • Grigory Sidorenkov

  • Rozemarijn Vliegenthart

  • Marjolein A. Heuvelmans

  • October 7, 2026

Share

  • 1

    This retrospective cohort study examined associations between CT nodule characteristics and histologic subtypes in lung cancers detected through the NELSON screening trial.

  • 2

    The study included high-risk current or recent smokers aged 50 to 74 years who underwent baseline LDCT and 3 subsequent screening rounds.

  • 3

    Blinded thoracic radiologists assessed nodule diameter, volume, attenuation, location, and volume doubling time using standardized NELSON protocols.

  • 4

    Histologic diagnoses were obtained from national pathology registries and classified according to the WHO classification of lung tumors.

  • 5

    Two experienced radiologists retrospectively matched cancer diagnoses to index nodules using anatomical and morphological criteria, resolving discrepancies by consensus.

Original Source(s)

Associations between CT characteristics of lung cancer lesions and histologic subtypes in lung cancer screening

  • by Erick Suazo-Zepeda, Geertruida H. de Bock, Noa Antonissen, Colin Jacobs, Firdaus A. A. Mohamed Hoesein, Hester A. Gietema, Grigory Sidorenkov, Rozemarijn Vliegenthart, Marjolein A. Heuvelmans

  • October 7, 2026

Related Content

SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial

Correction to: HLA Class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC

What the Biggest ASCO Cancer Research Updates Could Mean for Patients

Each year, the American Society of Clinical Oncology Annual Meeting brings together cancer specialists from around the world to share the research most likely to shape the next chapter of cancer care. This year’s major updates point to several important themes: more precise treatment, smarter use of surgery and chemotherapy, new approaches for difficult-to-treat cancers and a growing recognition that supportive care, including exercise, can be part of cancer treatment planning.

  • by

  • June 8, 2026

  • 10 min