Evaluating Adverse Reactions and Perceived Advantages of Pharmacotherapy in Pediatric Patients with Chronic Non-Cancer Pain

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Adverse effects occurred in 81% of pediatric patients within the first month of pharmacologic therapy for chronic non-cancer pain.
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Gastrointestinal and attention-related issues were the most common adverse effects reported by patients receiving pharmacotherapy.
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77% of patients reported perceived benefits from pharmacologic interventions, including pain relief and improved sleep.
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The number of perceived benefits increased with polypharmacy, but the benefits per prescription decreased as more medications were prescribed.
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The study highlights the need for safety monitoring and informed decision-making in pediatric pharmacotherapy for chronic pain.

Frontiers In Pain Research

by Kacper Niburski, Nada Mohamed, Dominique Dundaru-Bandi, Victor Hugo Gonzalez Cardenas, Marie Vigouroux, Rebecca Pitt, Pablo Ingelmo
April 20, 2026

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