Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis - Takeaways - MDSpire

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis

  • By

  • Hiromu Fukuda

  • Yoshito Hayashi

  • Shinji Yoneda

  • Yujiro Adachi

  • Ayaka Tajiri

  • Eiji Kimura

  • Ryotaro Uema

  • Takeo Yoshihara

  • Yoshiki Tsujii

  • Takahiro Kodama

  • Tetsuo Takehara

  • June 29, 2026

  • 0 min

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  • 1

    Colorectal cancer (CRC) is increasingly diagnosed in individuals under 50, known as early-onset CRC (EO-CRC), with a rising incidence of 1.4% annually.

  • 2

    EO-CRC often presents at a more advanced stage due to delayed diagnosis and has higher biological malignancy compared to late-onset CRC (LO-CRC).

  • 3

    Lymph-node metastasis (LNM) occurs in approximately 10% of patients with T1 CRC, making the assessment of LNM risk crucial for management.

  • 4

    The study aims to compare LNM rates between EO- and LO-T1 CRC through a systematic review and meta-analysis of previously published reports.

  • 5

    Eligibility criteria for the meta-analysis included studies reporting age-specific LNM rates in T1 CRC, with a focus on patients diagnosed at age < 50.

Original Source(s)

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis

  • by Hiromu Fukuda, Yoshito Hayashi, Shinji Yoneda, Yujiro Adachi, Ayaka Tajiri, Eiji Kimura, Ryotaro Uema, Takeo Yoshihara, Yoshiki Tsujii, Takahiro Kodama, Tetsuo Takehara

  • June 29, 2026

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