Transdermal entry of a non-pathogenic filamentous fungus Aspergillus oryzae induces an immunomodulatory response in skin-draining lymph nodes - Takeaways - MDSpire

Transdermal entry of a non-pathogenic filamentous fungus Aspergillus oryzae induces an immunomodulatory response in skin-draining lymph nodes

  • By

  • Thanh Dat Ta

  • Madoka Ozawa

  • Yuka Kasuga

  • Midori Shida

  • Yui Kotani

  • Haruko Hayasaka

  • Michio Tomura

  • Eiji Umemoto

  • Tomoya Katakai

  • June 15, 2026

  • 0 min

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  • 1

    Aspergillus oryzae (Ao) is a non-pathogenic filamentous fungus traditionally used in Japanese fermentation.

  • 2

    Subcutaneous inoculation of Ao in mice led to significant enlargement of skin-draining lymph nodes and increased immune cell numbers.

  • 3

    The immune response to Ao was characterized by increased activated B cells and type 2 resident dendritic cells.

  • 4

    Ao entry induced a mild immune response with increased IL-4 expression and development of immune memory without enhancing responses to other antigens.

  • 5

    Pre-inoculation with Ao inhibited allergic responses, suggesting its potential immunomodulatory effects.

Original Source(s)

Transdermal entry of a non-pathogenic filamentous fungus Aspergillus oryzae induces an immunomodulatory response in skin-draining lymph nodes

  • by Thanh Dat Ta, Madoka Ozawa, Yuka Kasuga, Midori Shida, Yui Kotani, Haruko Hayasaka, Michio Tomura, Eiji Umemoto, Tomoya Katakai

  • June 15, 2026

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