Lower serum 25-hydroxyvitamin D levels predict higher risk of DSPN in type 2 diabetes, and exhibit a non-linear association with the severity of DSPN - Takeaways - MDSpire

Lower serum 25-hydroxyvitamin D levels predict higher risk of DSPN in type 2 diabetes, and exhibit a non-linear association with the severity of DSPN

  • By

  • Tao Chen

  • Yi Feng

  • July 13, 2026

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  • 1

    Lower serum 25-hydroxyvitamin D levels are significantly associated with an increased likelihood of distal symmetric polyneuropathy in type 2 diabetes patients.

  • 2

    Individuals with distal symmetric polyneuropathy had mean 25-hydroxyvitamin D levels of 23.95 ng/mL, compared to 32.31 ng/mL in non-DSPN individuals.

  • 3

    A nonlinear relationship exists between 25-hydroxyvitamin D levels and the severity of distal symmetric polyneuropathy, with a critical threshold at 26.1 ng/mL.

  • 4

    As serum 25-hydroxyvitamin D levels drop below 26.1 ng/mL, the severity of distal symmetric polyneuropathy increases significantly.

  • 5

    The study utilized multivariable logistic regression and propensity score matching to validate the relationship between vitamin D levels and DSPN.

Original Source(s)

Lower serum 25-hydroxyvitamin D levels predict higher risk of DSPN in type 2 diabetes, and exhibit a non-linear association with the severity of DSPN

  • by Tao Chen, Yi Feng

  • July 13, 2026

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