Primary orbital solitary fibrous tumor with an 18-year course of five recurrences and extensive sinonasal metastasis following eyeball enucleation: a case report

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Orbital solitary fibrous tumor (OSFT) is a rare neoplasm that can exhibit aggressive behavior, leading to multiple recurrences and extensive local invasion.
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The case study reports an 18-year disease course in a female patient with five surgical interventions due to recurrent OSFT.
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Histopathological analysis confirmed the diagnosis of SFT, showing increased cellular atypia and a Ki-67 proliferation index of approximately 20% in the latest recurrence.
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Orbital exenteration was performed after the fourth recurrence, but a fifth recurrence occurred with extensive paranasal sinus invasion.
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The study advocates for early complete surgical excision and adjuvant radiotherapy, along with lifelong surveillance to improve long-term outcomes.

Frontiers In Medicine

by Jiayin Cai, Yijia Zhang, Jiabei Xiong, Xiaoxiao Luo, Yiyao Wang, Yongping Hu, Xiaolin Cao, Jianguang Zhong, Jian Li
May 22, 2026

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