Preoperative high-sensitivity C-reactive protein-to-albumin ratio predicts arteriovenous fistula failure in hemodialysis patients: a retrospective cohort study with landmark analysis - Takeaways - MDSpire
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Preoperative Ratio of High-Sensitivity C-Reactive Protein to Albumin as a Predictor of Arteriovenous Fistula Failure in Hemodialysis Patients: A Retrospective Cohort Analysis with Landmark Assessment

  • By

  • Shanshan Huo

  • Peng Shu

  • Zhuping Wen

  • Xiaodi Ma

  • Shuang Wang

  • Fang Xu

  • September 9, 2026

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  • 1

    The study analyzed 279 patients undergoing first-time arteriovenous fistula (AVF) creation to evaluate the high-sensitivity C-reactive protein-to-albumin ratio (HRR).

  • 2

    AVF failure occurred in 50.5% of patients during a median follow-up of 50 months, with HRR showing a significant association with increased failure risk.

  • 3

    Multivariable analysis indicated that each unit increase in HRR was linked to a 65% higher risk of AVF failure, independent of vessel diameter.

  • 4

    The model demonstrated moderate discrimination at 24 months (AUC = 0.608) and indicated positive net clinical benefit from incorporating HRR in risk assessment.

  • 5

    The findings suggest that preoperative HRR may help identify high-risk patients for AVF failure, although external validation of the results is necessary.

Original Source(s)

Preoperative high-sensitivity C-reactive protein-to-albumin ratio predicts arteriovenous fistula failure in hemodialysis patients: a retrospective cohort study with landmark analysis

  • by Shanshan Huo, Peng Shu, Zhuping Wen, Xiaodi Ma, Shuang Wang, Fang Xu

  • September 9, 2026

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