Non-linear saturation threshold of gonadotropin dose on cumulative live birth rates in advanced-age women with polycystic ovary syndrome: a retrospective cohort study - Takeaways - MDSpire
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Threshold Effects of Gonadotropin Dosing on Cumulative Live Birth Rates in Older Women with Polycystic Ovary Syndrome: A Retrospective Analysis

  • By

  • Yusi Han

  • Chunxiao Wei

  • Xinhua Wang

  • Jianwei Zhang

  • May 20, 2026

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  • 1

    Cumulative live birth rates (CLBR) were significantly lower in advanced-age PCOS patients compared to younger cohorts.

  • 2

    A non-linear relationship between total gonadotropin dose and CLBR was identified, with a saturation threshold at approximately 1,600 IU.

  • 3

    In the advanced-age subgroup, each 100-IU increase in gonadotropin dose below the threshold was associated with higher odds of CLBR.

  • 4

    Endometrial thickness (EMT) showed a stable positive linear association with CLBR, increasing from 32.5% at 6 mm to 66.1% at 22 mm.

  • 5

    A predictive nomogram incorporating age, EMT, transfer type, AFC, and Gn dose demonstrated moderate discrimination and adequate calibration.

Original Source(s)

Non-linear saturation threshold of gonadotropin dose on cumulative live birth rates in advanced-age women with polycystic ovary syndrome: a retrospective cohort study

  • by Yusi Han, Chunxiao Wei, Xinhua Wang, Jianwei Zhang

  • May 20, 2026

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