Anti-NMDA-receptor encephalitis and MOGAD associated optic neuritis: a case series - Takeaways - MDSpire

Anti-NMDA-receptor encephalitis and MOGAD associated optic neuritis: a case series

  • By

  • Pooja Parthasarathi

  • Michael Dattilo

  • Jason Peragallo

  • July 10, 2026

  • 0 min

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  • 1

    Three patients with anti-NMDAR encephalitis and MOGAD optic neuritis were presented, highlighting the clinical overlap between these conditions.

  • 2

    All patients exhibited abnormal MRI findings, including optic nerve enhancement and T2/FLAIR lesions during their encephalitis episodes.

  • 3

    Each patient tested positive for CSF anti-NMDAR antibodies during encephalitis and had positive serum MOG titers during optic neuritis.

  • 4

    Treatment varied among patients, including IV steroids, plasma exchange, rituximab, and tocilizumab, with visual acuity improving post-treatment.

  • 5

    The study emphasizes the need for monitoring visual symptoms in patients with anti-NMDAR encephalitis due to potential optic neuritis development.

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