Hydrocephalus as a consistent predictor of in-hospital mortality in tuberculous meningitis: no age-specific effect modification in a lifespan cohort - Takeaways - MDSpire

Hydrocephalus as a consistent predictor of in-hospital mortality in tuberculous meningitis: no age-specific effect modification in a lifespan cohort

  • By

  • Qiong Wu

  • Xiangzhi Xiao

  • Huashan Zhou

  • Yan Ouyang

  • Sufen Chen

  • Jue Hu

  • Yanhua Zhou

  • Wengao Zeng

  • July 16, 2026

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  • 1

    Tuberculous meningitis (TBM) has a high in-hospital mortality rate of 11.9%, despite advancements in treatment.

  • 2

    Hydrocephalus is independently associated with increased mortality risk in TBM patients across all age groups.

  • 3

    No significant interaction between hydrocephalus and age was found, indicating a consistent mortality risk across different ages.

  • 4

    Older age correlates with increased predicted mortality in TBM patients with hydrocephalus, particularly in older individuals.

  • 5

    The study utilized robust statistical methods to ensure accurate assessment of the relationship between hydrocephalus and mortality.

Original Source(s)

Hydrocephalus as a consistent predictor of in-hospital mortality in tuberculous meningitis: no age-specific effect modification in a lifespan cohort

  • by Qiong Wu, Xiangzhi Xiao, Huashan Zhou, Yan Ouyang, Sufen Chen, Jue Hu, Yanhua Zhou, Wengao Zeng

  • July 16, 2026

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