Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock - Takeaways - MDSpire

Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock

  • By

  • Fatma Karakoc Ozudogru

  • Banu Karaca

  • Huriye Erbak Yilmaz

  • Oguz Karalar

  • Murat Aksun

  • Kamil Gonderen

  • March 13, 2026

  • 0 min

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  • 1

    Sepsis remains a leading cause of morbidity and mortality in ICU patients, with high global incidence and mortality rates.

  • 2

    Current biomarkers like C-reactive protein and procalcitonin are insufficient for effective prognostication in sepsis.

  • 3

    Interleukin-6 levels correlate with poor prognosis and mortality in severe sepsis and septic shock patients.

  • 4

    Neuropilin-1 and Amphiregulin may provide additional prognostic information beyond established clinical risk scores.

  • 5

    This study evaluated the prognostic significance of IL-6, Nrp-1, and AREG in predicting 28- and 90-day mortality in sepsis patients.

Original Source(s)

Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock

  • by Fatma Karakoc Ozudogru, Banu Karaca, Huriye Erbak Yilmaz, Oguz Karalar, Murat Aksun, Kamil Gonderen

  • March 13, 2026

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