Prediagnostic Parkinson clues differ in strength

Some of the strongest prediagnostic Parkinson signals were among the least frequently documented.

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REM sleep behavior disorder, mild cognitive impairment, and orthostatic hypotension were identified as key nonmotor features before Parkinson disease diagnosis.
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REM sleep behavior disorder showed the strongest association with Parkinson disease, with nearly 10-fold higher odds in affected patients.
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Mild cognitive impairment and orthostatic hypotension were also associated with higher odds of Parkinson disease, at approximately 4-fold and 83% higher, respectively.
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Depression and anxiety were less consistently associated with Parkinson disease compared to the three primary features identified.
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The study utilized a matched case-control design with 2,673 patients and highlighted the underdocumentation of REM sleep behavior disorder in routine care.

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