The onco-functional reorganization of language network underlying metaplasticity induced by gliomas

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The study included 100 glioma patients and 127 matched controls to investigate language network reorganization using fMRI.
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Activation analyses revealed right-hemispheric lateralization in language networks associated with glioma-induced reorganization patterns.
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Task demands increased positive effective connections in the reorganized language network, influenced by linguistic complexity and functional integrity.
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ANOVAs indicated that changes in language network topology were linked to the flexible engagement of domain-general network components.
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The findings suggest that glioma-related network metaplasticity may inform personalized surgical strategies for functional protection.

Frontiers In Oncology

by Lu Jin, Zentao Zuo, Jie Kang, Fangzheng Liu, Yifan Song, Xin Liu, Kefan Cai, Wentao Wu, Chuzhong Li, Yazhuo Zhang, Songbai Gui
May 29, 2026

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